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KMID : 0377519850100010043
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Chung-Ang Journal of Medicine
1985 Volume.10 No. 1 p.43 ~ p.50
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Effect of Banadate on teh Action Potential by the Locations in the Rabbit S-A node
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Abstract
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In order to investigate the effect of vanadate on the action potentials of the rabbit S-A node, 3 M KCI glass microelectrodes were :introduced and analyzed in the central, transitional and peripheral areas in various strips which were prepared from a whole rabbit S-A node.
The followings were results of findings:
1. In cases of vanadate 320pM/l treatment, spontaneous firing rates were decreased to 78.76. 94, 78.5-3.35 and 64.57.42% of the controls respectively in the central, transitional and peripheral areas.
2. Maximum diastolic potentials (M.D.P.) were slightly increased in all three areas.
3. Overshoot potentials were increased at the central and peripheral areas but decreased at the transitional area in the vanadate-treated group.
4. Maximum depolarization rate(Vmax) were increased in all three areas.
5. Changes of the action potential induced by vanadate were qualitatively similar to those occuring when the calcium concentration of the bathing medium was raised to 4 mM.
These results may be interpreted as that vanadate increase the rate of Cat+ influx into all the cells in the S-A node.
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